Overall, the current iteration of the iSCORE-PD collection includes 65 clonal cell lines carrying high-risk or causal variants in 11 genes linked to PD (SNCA A53T, SNCA A30P, PRKN Ex3del, PINK1 Q129X, DJ1/PARK7 Ex1–5del, LRRK2 G2019S, ATP13A2 FS, FBXO7 R498X/FS, DNAJC6 c.801 A>G/FS, SYNJ1 R258Q/FS, VPS13C A444P/FS, VPS13C W395C/FS, GBA1 IVS2+1/FS) and isogenic control lines. The gene discussed is LRRK2; the disease is Parkinson disease.