We used state-of-the-art genome editing approaches to establish a total of 65 clonal cell lines carrying disease-causing or high-risk PD-associated mutations in 11 genes (SNCA, PRKN, PINK1, DJ1/PARK7, LRRK2, ATP13A2, FBXO7, DNAJC6, SYNJ1, VPS13C, and GBA1), along with isogenic control lines. This evidence concerns the gene LRRK2 and Parkinson disease.