ANKH and Alzheimer disease: Joint stiffness is absent in Ank+/KI mice and patients with AD CMD; 4) Cx43KI/KI mice develop more hypersclerotic diaphyseal cortical bone than AnkKI/KI mice; 5) Cx43KI/KI mice have milder narrowing of cranial foramina than AnkKI/KI mice; 6) Only Cx43KI/KI mice progressively develop irregular bone bossing at multiple sites.