ARHGEF28 and hepatocellular carcinoma: Among the variants shared for both traits, only 5 (MYRF, TECTB, DNM3, FAM101A and TSC22D2 loci) were associated with chronic liver disease, and 4 with cirrhosis (TFCP2, ABO, ARHGEF28 and TSC22D2 loci). Strikingly, there was an enrichment of variants associated with hepatocellular carcinoma (HCC) in the variants deriving from cT1 (44%, one-sided Fisher’s exact test p-value = 0.035), but not in PDFF (6%).