The combined use of SBI-756, an inhibitor of EIF4G1, and TNFSF10 in H1299 cells revealed that SBI-756 promoted TNFSF10-induced necrosis of tumor cells at lower concentrations, which suggested that EIF4G1-augmented TNFRSF10A expression significantly increased the sensitivity of lung cancer cells to TNFSF10. The gene discussed is TNFSF10; the disease is lung carcinoma.