CXCL8 and neoplasm: The concentration of CXCL8 in the supernatant of the cell culture medium gradually increased with the addition of increasing concentrations of SBI-756 in H1299 cells (Figure 4B).TNFSF10 has the ability to promote necrotic cell death in tumor cells; therefore, we compared the effects of adding 0, 1, and 2 μM SBI-756 to H1299 cells while adding 0, 0.01, 0.1, 1, 10, and 20 nM of recombinant TNFSF10 and tested cell survival.