CXCL8 and melanoma: By contrast, C-X-C motif chemokine ligand 8 (CXCL8), is an important molecule among the inflammation-related cytokines, playing many vital roles in tumors, including promoting the proliferation of pancreatic cancer cells, affecting the migration and invasion of melanoma, promoting tumor angiogenesis and affecting the tumor immune microenvironment via chemotaxis of neutrophils, macrophages, and endothelial cells (Vandercappellen et al., 2008; Legler et al., 2018).