The upregulation of CXCL8 expression caused by EIF4G1 knockdown promoted macrophage chemotaxis, and the addition of MK7123, a receptor inhibitor of CXCL8, inhibited this process in a dose-dependent manner, suggesting that the chemotaxis of macrophages toward lung cancer cells is mainly dependent on CXCL8. This evidence concerns the gene EIF4G1 and lung carcinoma.