Our investigation uncovered that the therapeutic intervention of APS exhibited a significant reduction in activation of neuroglial cells, concurrently with the suppression of key PICs, namely, IL-1β, IL-6, and TNF-α in both the Hip and cortex regions of the PTZ-induced kindling mouse model, indicating APS’ anti-inflammatory properties. The gene discussed is IL6; the disease is autoimmune polyendocrinopathy.