However, TKIs can induce vascular endothelial damage, hypertension and myocardial injury by targeting VEGFR, platelet-derived growth factor receptor (PDGFR) and stem cell factor receptor (SCFR) (van Cruijsen et al., 2009; Lennartsson and Rönnstrand, 2012). The gene discussed is KDR; the disease is Hypertension.