TP53 and cancer: All the compoundswere synthesized and subjected to biological screening on two BTK-expressingcancer cell lines, RAMOS and K562; six non-BTK cancer cell lines,A549, HCT116 (parental and p53–/–), U2OS,JURKAT, and CCRF-CEM; and two non-malignant fibroblast lines, BJ andMRC-5.