Analogous CD8+ memory T-cell subsets exist: Tc2, Tc17, and Tc22 cells express IL-6R but not SLAMF7, completely lack cytotoxicity and instead display helper functions including CD40L expressionCD8+ Th cells exhibit a unique TCR repertoire, express genes related to skin TRM and are altered in the inflammatory skin disease PsO. Here, CD8A is linked to inflammatory skin disease.