Human arthritic joints contain distinct subsets of TRM cellsCD8+CD69+CD103+ TRM cells: cytotoxic and Treg like TRM cells are present in both PsA and RAPsoriatic and rheumatoid arthritis joints differ in TRM subset compositionPsoriatic arthritis is enriched for pro-inflammatory type 17 TRM CD8+ cells with a pro-inflammatory cytokine profile (IL-17A+TNFα+ IFN-γ+)Rheumatoid arthritis is enriched for T cells with a cytotoxic profile. The gene discussed is TNF; the disease is arthritic joint disease.