AIF1 and Alzheimer disease: Under a high-fat diet, endogenous melatonin reduction (EMR) mice showed decreased anti-stress ability and had greater body weight and more obvious hepatic steatosis compared with the wild-type group; furthermore, 8-month-old EMR mice had AD-like phenotypes, including Iba-1 activation, Aβ protein deposition, and decreased spatial memory ability (51).