The transforming growth factor Tgfβ1 is known to be involved in neuroprotection after cerebral hypoxia and ischemia, and has been previously discussed in blood (Yan et al., 2022) and the context of multiple sclerosis (Wight et al., 2020), ischemic brain injury (Asplund et al., 2010; Dhandapani, 2003), stroke (Paulus et al., 1996), and cerebrovascular diseases (Hernández et al., 2021). This evidence concerns the gene TGFB1 and cerebrovascular disorder.