For instance, obesity‐induced inflammation led to hypomethylation of the promoter regions of oncogenes such as Nanog homeobox, POU class 5 homeobox 1 (POU5F1), and MYC proto‐oncogene (MYC) in colon cells, which may eventually cause colon cancer.40 This evidence concerns the gene POU5F1 and obesity due to melanocortin 4 receptor deficiency.