In a simulated state of excessive obesity using mature adipogenic medium, lncRNA plasmacytoma variant translocation 1 (PVT1) promoted cell epithelial‐mesenchymal transition (EMT) and enhanced cell viability and migration ability of TNBC cells by inhibiting the expression of cancer suppressor gene p21.122. This evidence concerns the gene PVT1 and obesity due to melanocortin 4 receptor deficiency.