Downregulation of lncRNA five prime to Xist (FTX) and overexpression of lncRNA small nucleolar RNA host gene 20 (SNHG20) promoted the development of nonalcoholic fatty liver disease (NAFLD) into HCC by modulating the polarization of Kupffer cells.124, 125. This evidence concerns the gene FTX and metabolic dysfunction-associated steatotic liver disease.