Ghrelin, a polypeptide with cardioprotective properties, has been observed to target the lncRNA H19/miR‐29a/insulin‐like growth factor 1 (IGF‐1) signaling pathway and the lncRNA HOTAIR/miR‐196b/IGF‐1 signaling pathway, thereby mitigating cardiomyocyte injury associated with obesity.138, 139. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.