Especially in eye diseases, for example, studies have shown that genetic variations in lipid metabolism and transport genes—such as liver lipase, cholesterol ester (CE) transferase, apolipoprotein (Apo) E and ATP binding cassette (ABC) transport protein A1—are associated with an increased risk of age‐related macular degeneration (AMD)7, 8, 9; and the therapeutic effect of reverse cholesterol transport (RCT) pathway in eye diseases also has become a recent research hotspot10; in addition, the function of cholesterol in the intraocular lens is different from that in other tissues and organs. This evidence concerns the gene APOE and age-related macular degeneration.