In a study aimed at investigating the relationship between inflammation and cholesterol accumulation in HCC cells, the authors found that LPS increases intracellular cholesterol accumulation through the NF‐κB pathway in HCC cells, which in turn promotes LPS/NF‐κB pathway and inflammatory response, indicating the proinflammatory effect of cholesterol in HCC cells.108. Here, NFKB1 is linked to hepatocellular carcinoma.