The lungs from patients with different types of pulmonary fibrosis, including IPF, COVID‐19, and systemic sclerosis‐associated interstitial lung disease (ILD), and from mice with bleomycin‐induced pulmonary fibrosis are characterized by altered expression of methyl‐CpG‐binding domain 2 (MBD2) in macrophages. Here, MBD2 is linked to interstitial lung disease.