In both cases of MTB-infected and uninfected healthy individuals from a TB endemic area, M72/AS01E vaccination has been shown to generate an acceptable immunity and reactogenicity profile and produced potent and sustained CD4 and CD8 T cell responses, as well as CD4+ T cell dependent IFN- recall responses in NK cells [18], and two M72/AS01 doses produced higher immune responses than a single dose [19]. Here, CD4 is linked to tuberculosis.