LaBelle M et al. (Labelle et al., 2014) demonstrated that granulocyte recruitment depends on the secretion of chemokines CXCL5 and CXCL7 by activated platelets, and that chemokines CXCL5 and CXCL7, and blocking this process can effectively prevent the formation of the early PMN and thereby significantly reduce tumor metastasis (Figure 2A). The gene discussed is PPBP; the disease is neoplasm.