MDSCs (CD11b+Gr 1+) also promote angiogenesis by upregulating the expression of Bv8, a mediator of myeloid cell-dependent tumor vascularization, and the proportion of angiogenesis in the tumors of homozygous mice is significantly reduced by treatment with neutralizing Bv8-specific antibodies (Shojaei et al., 2007). Here, PROK2 is linked to neoplasm.