In in vitro experiments, co-incubation of platelets or platelet releasates from tumor-bearing mice with MDSCs revealed that platelets were able to considerably increase the ability of MDSCs to block T cell proliferation and increase the levels of Arginase-1(Arg-1) and C/EBPβ mRNA expression, consequently encouraging tumor development by assisting in immune evasion (Servais et al., 2018). Here, ARG1 is linked to neoplasm.