Breast Cancer: involved in lipid metabolism (Wang et al., 2017); regulates the ERα transcriptional response to EGF signaling, driving metastatic progression (Magnani et al., 2011; Magnani et al., 2015); reprogramming of the chromatin landscape (Magnani et al., 2013); prognostic marker (Ao et al., 2020). This evidence concerns the gene ESR1 and breast cancer.