Other PBX1 downstream effectors in MPN are the Mk marker CD61, which is downregulated upon PBX1 deletion in the murine MPN model, and the novel early myeloid differentiation marker Embigin, which is instead upregulated upon PBX1 deletion (Muggeo et al., 2021), although direct regulation has not been demonstrated. This evidence concerns the gene ITGB3 and myeloproliferative disorder.