Ganglioside-monosialic acid (GM1) gangliosidosis (ICD-10: E75.1; OMIM: 230500, 230600, 230650) is a rare autosomal recessive hereditary disease, lysosomal storage disorder caused by mutations in the <i>GLB1</i> gene that lead to the absence or insufficiency of β-galactosidase. This evidence concerns the gene GLB1 and lysosomal storage disease.