CNR1 and nervous system disorder: Expression of the cannabinoid receptor type 1 (CB1R) is mostly confined to the central nervous system (Matsuda et al., 1990), while CB2R expression is considered to be mainly located at the periphery (Munro et al., 1993), although potential clinical applications of targeting CB2R in neurological disorders have been highlighted recently (Kibret et al., 2022), likely due to microglial expression of CB2R (Tanaka et al., 2020).