CNR1 and schizophrenia: Indeed, many studies observed a direct relationship between altered CB1R availability in schizophrenia (Dean et al., 2001; Zavitsanou et al., 2004; Newell et al., 2006; Eggan et al., 2008; Urigüen et al., 2009; Wong et al., 2010; Dalton et al., 2011; Jenko et al., 2012; Ceccarini et al., 2013; Ranganathan et al., 2016; Muguruza et al., 2019; Bloch Priel et al., 2023) or during psychosis (Borgan et al., 2019b, 2021), which is also corroborated by animal models of schizophrenia (Szűcs et al., 2016; Stark et al., 2022).