TIGIT and astrocytoma (excluding glioblastoma): CD47 expression was not correlated with sex or pTERT mutations (Table 1); however, CD47 expression was higher in patients older than 50 years of age (P < 0.05) and in patients classified as GBM (P < 0.05) and was significantly associated with grade 4 in astrocytoma, whereas high expression of CD47 and TIGIT were related to the MGMT unmethylation status, respectively (P < 0.05).