Among 22 cases of low-grade glioma (LGG) with wild-type IDH, 12 patients had a median age of 53 (37–73) and were diagnosed with molecularly characterized GBM (10 cases had a pTERT mutation; two carried the EGFR amplification, one of which showed a chromosome 7 gain) (22). This evidence concerns the gene IDH1 and low grade glioma.