The significance of MBL and MBL deficiency in disease pathogenesis has been a source of ambiguity and queries as studies indicate that low or elevated MBL levels show a damaging, protecting, or no effect on susceptibility to diseases (51), which could also be the case here, as recent studies have revealed the important role of MBL in psoriasis pathogenesis. This evidence concerns the gene MBL2 and hyperinsulinemic hypoglycemia, familial, 4.