URI1 and liver cancer: The susceptibility of the interaction between URI1 and PP1c to disruption by PDP-Nal is of particular interest for further studies, as this interaction plays a role in survival signaling in liver cancer.51 At the same time, this 5 minutes PDP treatment of cells already led to remarkable changes in the phosphoproteome, which needs to be considered in their application as modulators of PP1 and as PhoRCs.