The susceptibility of the interaction between URI1 and PP1c to disruption by PDP-Nal is of particular interest for further studies, as this interaction plays a role in survival signaling in liver cancer.51 At the same time, this 5 minutes PDP treatment of cells already led to remarkable changes in the phosphoproteome, which needs to be considered in their application as modulators of PP1 and as PhoRCs. This evidence concerns the gene NPL and liver cancer.