Hazard ratios (HR) were calculated for the CPS and SPS groups for comparison with the SZC group (Fig. 4) by using the three models adjusted for various clinical factors: Model 1 includes no adjustment, so the model is equal to univariate analysis; Model 2 includes age and sex as adjustment factors; Model 3 uses history of hypertension, diabetes, heart failure, ischaemic heart disease, cerebrovascular disease, prescription of ARB, ACEi, beta blocker, SGLT2, and MRA at the start of the observation period in addition to Model 2. Here, SLC5A2 is linked to heart failure.