Its extracellular secretory components can be released in the form of secretory immunoglobulin A (sIgA), but the deficiency of pIgR will reduce the intestinal sIgA level and increase the intestinal barrier dysfunction, leading to more severe intestinal microbiota imbalance, increased bacterial migration, and accelerated development of AIH (Lin et al., 2023). The gene discussed is PIGR; the disease is autoimmune hepatitis.