PK severity measured by UPDRS-III was significantly associated with Prevotella intermedia, serum IL1beta levels, saliva IL1-beta levels and years of education (p = 0.006, 0.019, 0.034 and 0.005 respectively) (Table 5), while Hoehn &Yahr correlated with Porphyromonas gingivalis, Prevotella intermedia, RNA IL1-beta regulation, serum IL1-beta levels, saliva IL1-beta levels and duration of Parkinson`s disease with p-values of 0.038, 0.011, 0.008, <0.001, 0.010, and 0.001 (Table 6). Here, IL1B is linked to Parkinson disease.