The clinical manifestations of TNRC6B deficiency syndrome are heterogeneous, with a wide range of symptoms including facial dysmorphism, development delay (DD)/intellectual disability (ID), speech and language delay, fine and motor delay, attention deficit and hyperactivity disorder (ADHD), autistic features, seizures, skeletal defects, and variable behavioral abnormalities (Granadillo et al., 2020). The gene discussed is TNRC6B; the disease is Global developmental delay.