The phenotype of STAT3 GOF variant is characterized by lymphadenopathy with hepatosplenomegaly, postnatal growth retardation, immunodeficiency, and autoimmune disorders, including cytopenia, enteropathy, diabetes, thyroiditis, arthritis, atopic dermatitis, and interstitial lung disease (Fabre et al., 2018; Fabre et al., 2019; Giovannini‐Chami et al., 2019). The gene discussed is STAT3; the disease is immune system disorder.