The phenotype of STAT3 GOF variant is characterized by lymphadenopathy with hepatosplenomegaly, postnatal growth retardation, immunodeficiency, and autoimmune disorders, including cytopenia, enteropathy, diabetes, thyroiditis, arthritis, atopic dermatitis, and interstitial lung disease (Fabre et al., 2018; Fabre et al., 2019; Giovannini‐Chami et al., 2019). This evidence concerns the gene STAT3 and immunodeficiency disease.