Germline loss‐of‐function (LOF) variants in the STAT3 gene result in autosomal‐dominant hyperimmunoglobulin‐E syndrome (OMIM:147060) which is characterized by high serum IgE, eosinophilia, eczema, and immunodeficiency (Woellner et al., 2010). Here, STAT3 is linked to immune system disorder.