SIRT1 and acute kidney injury: To investigate the role of Sirt1 in the protective effect of agrimol B on CDDP-induced AKI, we used a specific inhibitor of Sirt1, EX527, to confirm the protective effects of agrimol B. The procedure for establishing the animal model is shown inFigure 6A. As expected, the kidney function indicators BUN and Scr showed that EX527 partially inhibited the renoprotective effect of agrimol B (Figure 6B,C).