To compare the prediction efficiency of the five‐protein classifier with other biomarkers in predicting mortality at the early stage of the COVID‐19, we collected the data of CRP, ages, the absolute value of lymphocyte and neutrophil, NLR, the 4C mortality and E‐CURB65 scores on the first admission day of the patients in discovery and validation groups and respectively calculated the AUCs of these factors in predicting mortality. Here, CRP is linked to COVID-19.