S100A8 and Alzheimer disease: S100A8+ microglia were identified in three out of 10 AD patients aged 57, 53, and 62 years, in one out of eight patients with tauopathies aged 51 years, and in one control individual aged 69 years, situated within the hippocampus and/or regions encompassing the parasubicular, subicular, and entorhinal cortices (Figure 6g–i).