Most of this work has been done on mouse models that display amyloidosis, but since cognitive impairment correlates more strongly with tau deposition than with amyloid plaque load, and since a variety of other neurodegenerative disorders are solely caused by tau pathology, there is growing interest in tau as possible mediator of disease (Giannakopoulos et al., 2003). Here, MAPT is linked to Cognitive impairment.