Additionally, the LADAM subpopulation was described to be derived from Early‐stage AD‐Associated Microglia (EADAM), which show high levels of interferon relative genes Irf7 and Isg15, or from a DAM2 subpopulation characterized by high levels of Spp1, Gpnmb, Apoe, Cst7, Cd74, Lpl, and Lgals3 (Kim et al., 2022). Here, ISG15 is linked to Alzheimer disease.