The possibility that the ipsilateral hemisphere represents a more advanced stage of tauopathy compared to the contralateral regions at the same timepoint, coupled with the observed lack of impact on phospho‐tau load with microglia depletion in this hemisphere (Figure S4), emphasizes that the DAM subpopulation does not necessarily drive tau propagation but is rather a consequence of tau pathology. This evidence concerns the gene MAPT and tauopathy.