In the transplanted tumor tissues of nude mice constructed with H446 and H69 cells, the expressions of CD31 and Ki67 in tumor tissues were significantly decreased, and the expression of c‐caspase‐3 was significantly increased after the intervention of 80 or 120 mg/kg apatinib, both of which had statistically significant differences compared with the control group (P < 0.05). This evidence concerns the gene PECAM1 and neoplasm.