TNF and Blindness: Although the underlying pathophysiology of optic nerve compression-induced visual impairment is still being explored [14], some researchers believe that damage to retinal ganglion cells (RGC) caused by various factors further leads to a series of complex processes such as abnormal intracellular signaling pathways and the release of inflammatory factors such as interleukins and tumor necrosis factors, triggering an apoptotic program that ultimately leads to blindness [15].