The expression of ATG16L1 could be targeting regulated by a variety of micro-RNA, including miR-106b found in intestinal epithelial HCT116 cells, and four microRNA (miR-106a [59], miR-874 [60], miR-410 [61], and miR-223 [62]) found in cancer or other inflammation disease, which may provide pharmaceutical strategies for developing small molecule drugs for CD. The gene discussed is ATG16L1; the disease is Cowden disease.