COMP and intervertebral disk degenerative disorder: Upregulated FOS has been associated with the development of IDD[29] and inhibition of AP1 has been shown to result in an inhibition of disc degeneration.[30] Additionally, genes encoding core matrisome proteins such as COMP, CILP, COL9A3, and COL2A1 were upregulated in diseased (Figure 7H).