Additionally, THBS1 has been shown to promote fibrosis both through TGFβ and independently of TGFβ[60] and to play a major role in other fibrosis‐related diseases such as hepatitis[61] and diabetes.[62] These data suggest a role of THBS signaling in disease progression, and also are indicative of promotion of fibrosis and tissue remodeling, which are characteristic features of degenerated NP. This evidence concerns the gene THBS1 and Hepatitis.