In turn, we also observed that overexpressing NSUN2 could partly reverse the blockaded NRF2 expression in NRF2-knockdown A549 cells (Fig. 6L), as well as the repressed cell viability (Fig. 6M) and upregulated MDA levels (Fig. 6N), which results suggest that NRF2 is a potential target of NSUN2, and NSUN2 may bolster NSCLC ferroptosis tolerance by enhancing NRF2 protein expression in vitro. Here, NFE2L2 is linked to non-small cell lung carcinoma.