NFE2L2 and neoplasm: Additionally, the HE staining of NSUN2 overexpression xenograft tumors exhibit increased tumor malignancy state, and the immunohistochemistry staining also verified that the tumors promoting growth that emerged from A549 cells with NSUN2 overexpression exhibited heightened levels of Ki-67 and NRF2 as well as GPX4 and FTH1 (Fig. 9D).