IP6K1 and infertility disorder: Moreover, IP6K1 was shown to be involved in spermatogenesis (76), and IP6K1 knockout in male mice leads to sterility (50) due to the absence of chromatoid bodies in IP6K1 knockout spermatids, which are ribonucleoprotein granules involved in control of mRNA translation, mRNA decay, and small RNA-mediated gene regulation (77).