APLN and Cushing syndrome due to macronodular adrenal hyperplasia: A chordal map was used to visualize the top five KEGG-enriched pathways, including the peroxisome proliferator-activated receptor (PPAR) signaling pathway, cholesterol metabolism, apelin signaling pathway, cytokine‒cytokine receptor interaction and Cushing syndrome (Additional file 3: Fig. S1A).