PPARG and pulmonary arterial hypertension: For the heart, an organ that primarily utilizes fatty acids, Pparg deficiency leads to ventricular contractile dysfunction and intracellular fatty acid overload in cardiomyocytes in mice, whereas pioglitazone, an agonist of Pparg, reverses hypoxia-induced pulmonary hypertension and ventricular remodeling in rats [50].