SIRT6 and Myocardial fibrosis: A report found that SIRT6 in rat vascular endothelial cells improves cardiac diastolic function by inhibiting PPARγ expression in endothelial cells [46], while another article suggested that PPARγ activation may reduce systolic blood pressure and left ventricular mass and attenuate myocardial fibrosis in HFpEF rats by inhibiting the Wnt-β-catenin pathway [47].