MDM2 and gastric cancer: The MDM2 siRNA (Table 2) was used to inhibit the expression of MDM2 and western blots was used to detect MDM2 protein levels in AGS and HGC27 cells, the results showed MDM2 siRNA can significantly interfere MDM2 protein level in the two GC cell lines (Fig. 7a) (P < 0.01).