The results of echocardiography, cardiac organ coefficients, serum heart failure markers Elisa assay, and histopathology showed that ONSMP differentially increased LVEF, LVFS, LVSd, LVSs, LVPWd, LVPWs, E/A, SI, and TIMP-1, and decreased LVIDd, LVIDs, HWI, LVWI, HW/TL, LVW/TL, ANP, BNP, NT-ProBNP, PICP, MMP-2, and MMP-9, attenuating the extent of myocardial injury, and reducing the size of myocardial fibrotic areas. This evidence concerns the gene NPPB and heart failure.