In hyperglycemia, the antioxidant capabilities of the Hp protein are impaired among people with the Hp2-2 phenotype (~ 40% worldwide [10]) relative to the non-Hp2-2 phenotypes (Hp1-1and Hp2-1), and high-density lipoprotein (HDL) has been shown to be dysfunctional and pro-atherogenic with the potential to increase susceptibility to atherosclerosis, and ultimately CAD [7, 11–13]. This evidence concerns the gene HP and Hyperglycemia.