Additionally, genes in the SMAD binding category, such as SMAD3, SMAD6, the SMAD specific E3 ubiquitin protein ligase 2 (SMURF2), and the transforming growth factor beta receptor 1 (TGFBR1/ALK5), had fewer H3K27ac peaks in the endometrial stromal cells from individuals with endometriosis, corroborating our previous transcriptomic results in which a dysfunctional TGFβ/BMP signaling pathway was identified in the decidualizing stromal cells from individuals with endometriosis (Fig. 4E, Supplementary Data File 6). Here, SMAD6 is linked to endometriosis.