Overall, we found that out of the 512 DEGs in the endometriosis dataset at Day 4 EPC, 90 (17.5%) also shared both a SMAD4 and H3K27Ac peak, while 15 (2.9%) shared only a SMAD4 peak, and 282 (55%) shared only an H3K27Ac peak (Supplementary Data File 6). The gene discussed is SMAD4; the disease is endometriosis.