GRIK3 and Anxiety: Importantly, GluK3 KO mice also showed a significantly increased time spent in the closed arm (t(20) = 3.045, p = 0.0064, Fig. 6b) and a reduced time in the open arm (t(18) = 1.866, p = 0.0784, Fig. 6b), suggesting that risperidone affects the anxiety-like behavior on both WT and GluK3 KO mice when examined by the elevated plus maze test (Fig. 6c).