In malignant brain tumors (Glioma), B7-H6 (B7 homologue 6) is expressed abnormally and RNMT expression was significantly decreased in B7-H6 knock-down glioma stem-like cells (GSLCs) suggesting RNMT role in B7-H6 tumor cell proliferation enhancement via the c-Myc/RNMT Axis. This evidence concerns the gene NCR3LG1 and central nervous system cancer.