In malignant brain tumors (Glioma), B7-H6 (B7 homologue 6) is expressed abnormally and RNMT expression was significantly decreased in B7-H6 knock-down glioma stem-like cells (GSLCs) suggesting RNMT role in B7-H6 tumor cell proliferation enhancement via the c-Myc/RNMT Axis. The gene discussed is RNMT; the disease is brain cancer.