Notably, CPN2 (carboxypeptidase N Subunit 2), F5 (coagulation factor V), ECM1 (extracellular matrix protein 1), KNG1 (kininogen 1), FN1 (fibronectin 1), and GPLD1 (glycosylphosphatidylinositol-specific phospholipase D1) were found to be elevated in both human and mouse sEVs under obesity conditions. The gene discussed is GPLD1; the disease is obesity due to melanocortin 4 receptor deficiency.