PGK1 and colorectal carcinoma: In summary, we propose a potential mechanism by which PRMT1 enhances CRC glycolysis and tumorigenesis by mediating PGK1 arginine dimethylation modification at R206, which promotes ERK-mediated PGK1 phosphorylation at S203 sites, and PRMT1, meR206-PGK1, and pS203-PGK1 may be reliable combinational biomarkers for CRC prognosis.