PGK1 and neoplasm: Mechanistically, PRMT1 binds to PGK1 and methylates it at R206 (meR206-PGK1), which leads to increased ERK-mediated phosphorylation of PGK1 at S203, which phosphorylates pyruvate kinase and inhibits PDH complex-dependent pyruvate utilization in mitochondria, leading to increased glycolytic activity and tumor progression.