BRAF and colorectal carcinoma: Recent studies revealed that high F. nucleatum abundance in the tumor tissues was significantly associated with BRAF mutations and CpG island methylator phenotype (CIMP)-positive CRC patients in univariate analyses and the amount of F. nucleatum was also associated with microsatellite instable (MSI)-high tumors independent of CIMP and BRAF mutation status, supporting the notion that gut microbiota has links to the intratumor genetics and epigenetics of CRC29–31.