Recent studies revealed that high F. nucleatum abundance in the tumor tissues was significantly associated with BRAF mutations and CpG island methylator phenotype (CIMP)-positive CRC patients in univariate analyses and the amount of F. nucleatum was also associated with microsatellite instable (MSI)-high tumors independent of CIMP and BRAF mutation status, supporting the notion that gut microbiota has links to the intratumor genetics and epigenetics of CRC29–31. Here, BRAF is linked to neoplasm.