Figure 6A-C demonstrated that the tumor volumes and weights of tumors derived from the mixture of cancer cells and CAFs-miR-1290 mimics were significantly greater than those derived from the mixture of cancer cells and CAFs-NC, whereas those derived from the mixture of cancer cells and CAFs-lv-OGN were reduced than those derived from CAFs-NC; the effects of miR-1290 overexpression in CAFs were partially reversed by OGN overexpression (Fig. 6A-C). The gene discussed is OGN; the disease is cancer.