To investigate the role of the miR-1290/OGN axis in mediating CAFs functions on ovarian cancer cells in vivo, xenograft models were established in nude mice by subcutaneously injecting the mixture of SKOV3 cells along with CAFs or transfected CAFs (miR-1290 mimics/lv-OGN). The gene discussed is OGN; the disease is ovarian carcinoma.