Whereas, Serum Zonulin had significant positive correlation with WHTR (p = 0.001, p = 0.000), and HDL (p = 0.012).While, serum Copeptin had significant negative correlation with some obesity markers [WHR (p = 0.035), WHTR (p = 0.000)], fat distribution [most of the investigated skinfold thickness: BSF (p = 0.004), TSF (p = 0.018), SCSF (p = 0.021), ABSF (p = 0.004) and peripheral obesity index (p = 0.004)]. The gene discussed is AVP; the disease is obesity due to melanocortin 4 receptor deficiency.