Serum Zonulin showed significant negative correlation, whereas serum Copeptin showed significant positive correlations with the obesity markers: [BMI (p = 0.001, p = 0.000), WC (p = 0.006, p = 0.001), HC (p = 0.000), WHTR (p = 0.006, p = 0.002), SCSF (p = 0.002, p = 0.006)] and body composition [FM (p = 0.035, p = 0.009), FFM (p = 0.004, p = 0.000), TBW (p = 0.011, p = 0.001), and BMR (p = 0.006, p = 0.001)]. This evidence concerns the gene AVP and obesity due to melanocortin 4 receptor deficiency.