Among the obese group, levels of serum Zonulin revealed significant negative correlations, while Copeptin showed significant positive correlations with some obesity markers (BMI, WC, HC, WHTR, SCSF) and body composition (TBW, FFM and FM and BMR), and insignificant correlations with blood pressure and lipid profile. This evidence concerns the gene HP and obesity due to melanocortin 4 receptor deficiency.