Therefore, with prior knowledge of the excellent correlation between hs-cTnI and hs-cTnT in acute myocardial infarction, there is a very small number of studies investigating the predictive utility of the combination of hs-cTnT and hs-cTnI and such studies across glycemic status were even scarcer, even though the independent association between increased hs-cTn and worse CVD outcomes was well-recognized [24–26, 29–32]. This evidence concerns the gene TNNI3 and acute myocardial infarction.