Prediabetes behaved like an intermediate status between normoglycemia and diabetes, among whom the rPCE model demonstrated a compromised predictive performance, and adding either hs-cTnT or hs-cTnI to the rPCE model would improve 10-year cardiac-specific mortality predictions (Table 3) but the additive value of hs-cTnI to hs-cTnT was also not found (difference in AUC: 0.003; 95% CI − 0.003 to 0.009; P = 0.37). The gene discussed is TNNT2; the disease is diabetes mellitus.