Firstly, in a group without DM, consisting of 8,224 participants, the analysis adjusted for factors such as age, CRP, eGFR, sex, HDL-c, LDL-c, UA, CLD, PLT, Cystatin C, hypertension, HBA1C, CKD, smoking, drinking status. The gene discussed is CRP; the disease is congenital secretory chloride diarrhea 1.