In the present study, LIGHT regulation of baculoviral IAP repeat containing 3 (BIRC3), interleukin 7 receptor (IL7R), tumor necrosis factor receptor superfamily member 9 (TNFRSF9), synaptosomal-associated protein 25 kDa (SNAP25), and diaphanous-related formin 1 (DIAPH1) in RA-FLS was observed and classified into major functional clustering categories. Here, DIAPH1 is linked to rheumatoid arthritis.